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dEq

A PRODUCT BY APL

Predifined PK/PD models

This module allows to simulate PK/PD models using the differential equations. The following predefined PK/PD models are available in PKMP.

PK Models PD Models Single dose Multiple dose Cp or Cpe1
Extravascular Emax
Emax with baseline effect
Sigmoid Emax
Sigmoid Emax with baseline effect
Inhibition Emax
Inhibition Emax with baseline effect
Inhibition sigmoid Emax
Inhibition sigmoid Emax with baseline effect
Yes Yes Yes
1CBM
2CBM
IV Bolus
1CBM
2CBM
3CBM
IV Infusion
1CBM
2CBM
3CBM

1Cp and Cpe are plasma and effect compartment concentrations, respectively.

Integration methods available are:

  • Runge-Kutta (4th order) or,
  • Runge-Kutta-Cash-Karp or,
  • Runge-Kutta-Fehlberg

The following is an example of a PK/PD simulation.